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1996-03-09
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Document 0532
DOCN M9650532
TI HIV disease and Malassezia yeasts: a quantitative study of patients
presenting with seborrhoeic dermatitis.
DT 9605
AU Schechtman RC; Midgley G; Hay RJ; Medical Mycology Department, St John's
Institute of Dermatology,; St Thomas' Hospital, London, U.K.
SO Br J Dermatol. 1995 Nov;133(5):694-8. Unique Identifier : AIDSLINE
MED/96142527
AB Seborrhoeic dermatitis (SD) is a disease that affects 1-3% of the
general population, 3-5% of young adults and 20-83% of patients with
AIDS. Malassezia yeasts have been associated with the pathogenesis of
this condition. The association between the Malassezia yeasts and
HIV-related SD is still a controversial subject. The objective of our
study was to investigate the role of Malassezia yeasts in the
pathogenesis of SD in the HIV population comparing the number of yeasts'
cells with the severity of the disease and degree of immunosuppression.
We used two quantitative counting methods: direct counting with
Sellotape-stripped skin and recovery of the yeasts in culture using
contact plates. This investigation has demonstrated that there is a
trend between numbers of yeasts present on lesional skin, severity of SD
and CD4-positive T lymphocytes count in HIV-positive patients. No
quantitative differences were observed between HIV-related and non-HIV
related SD.
DE Adult Colony Count, Microbial CD4 Lymphocyte Count Dermatitis,
Seborrheic/COMPLICATIONS/*MICROBIOLOGY Dermatomycoses/*MICROBIOLOGY
Face Female Human HIV Infections/*COMPLICATIONS
Malassezia/*ISOLATION & PURIF Male Skin/MICROBIOLOGY Support,
Non-U.S. Gov't Thorax Tinea Versicolor/MICROBIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).